Reaction Details Report a problem with these data
Target
Cryptochrome-2
Ligand
BDBM356943
Substrate
n/a
Meas. Tech.
ChEMBL_1750223 (CHEMBL4184983)
EC50
487±n/a nM
Citation
  TBA Bioorg Med Chem Lett 28:293-297 (2018) [PubMed]  Article 
Target
Name:
Cryptochrome-2
Synonyms:
CRY2 | CRY2_HUMAN | Cryptochrome-2 | KIAA0658
Type:
PROTEIN
Mol. Mass.:
66958.43
Organism:
Homo sapiens
Description:
ChEMBL_118347
Residue:
593
Sequence:
MAATVATAAAVAPAPAPGTDSASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLASVPSCVEDLSHPVAEPSSSQAGSMSSAGPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA
  
Inhibitor
Name:
BDBM356943
Synonyms:
1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypropyl)-3- phenylpyrrolidin-2- one | US10214507, Compound 53 | US10759777, Compound 53
Type:
Small organic molecule
Emp. Form.:
C25H22F2N2O2
Mol. Mass.:
420.4512
SMILES:
OC(CN1CCC(C1=O)c1ccccc1)Cn1c2ccc(F)cc2c2cc(F)ccc12
Structure:
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