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Target
EH domain-containing protein 1
Ligand
BDBM50453873
Substrate
n/a
Meas. Tech.
ChEMBL_1751402 (CHEMBL4186162)
IC50
27100±n/a nM
Citation
 Kamens, AJ; Mientkiewicz, KM; Eisert, RJ; Walz, JA; Mace, CR; Kritzer, JA Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1. Bioorg Med Chem 26:1206-1211 (2018) [PubMed]  Article 
Target
Name:
EH domain-containing protein 1
Synonyms:
EH domain-containing protein 1 | EHD1 | EHD1_HUMAN | PAST | PAST homolog 1 | PAST1 | Testilin | hPAST1
Type:
PROTEIN
Mol. Mass.:
60628.64
Organism:
Homo sapiens
Description:
ChEMBL_118187
Residue:
534
Sequence:
MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE
  
Inhibitor
Name:
BDBM50453873
Synonyms:
CHEMBL4210179
Type:
Small organic molecule
Emp. Form.:
C55H67N9O14S2
Mol. Mass.:
1142.302
SMILES:
NC(=O)C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CSCc2ccc(CSCCNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H]3CCCN3C1=O)cc2)NC(=O)CCC#C |r|
Structure:
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