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Target
Midkine
Ligand
BDBM50454866
Substrate
n/a
Meas. Tech.
ChEMBL_1753624 (CHEMBL4188384)
IC50
254000±n/a nM
Citation
 Maza, S; Gandia-Aguado, N; de Paz, JL; Nieto, PM Fluorous-tag assisted synthesis of a glycosaminoglycan mimetic tetrasaccharide as a high-affinity FGF-2 and midkine ligand. Bioorg Med Chem 26:1076-1085 (2018) [PubMed]  Article 
Target
Name:
Midkine
Synonyms:
ARAP | Amphiregulin-associated protein | MDK | MK | MK1 | MK_HUMAN | Midgestation and kidney protein | NEGF2 | Neurite outgrowth-promoting factor 2 | Neurite outgrowth-promoting protein
Type:
PROTEIN
Mol. Mass.:
15605.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_805023
Residue:
143
Sequence:
MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD
  
Inhibitor
Name:
BDBM50454866
Synonyms:
CHEMBL4213376
Type:
Small organic molecule
Emp. Form.:
C35H50N2O36S4
Mol. Mass.:
1203.023
SMILES:
[H][C@@]1(O[C@H]2[C@H](OS(O)(=O)=O)[C@@H](COS(O)(=O)=O)O[C@@]([H])(O[C@H]3[C@H](O)[C@@H](O)[C@H](Oc4ccc(OC)cc4)O[C@@H]3C(O)=O)[C@@H]2NC(C)=O)O[C@@H]([C@@H](O[C@]2([H])O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](O)[C@H]2NC(C)=O)[C@H](O)[C@H]1O)C(O)=O |r|
Structure:
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