Target
D(2) dopamine receptor
Ligand
BDBM22875
Substrate
n/a
Meas. Tech.
ChEMBL_1760114 (CHEMBL4195122)
Ki
378±n/a nM
Citation
 Pa?czyk, KPytka, KJakubczyk, MRapacz, ASa?at, KFurga?a, ASiwek, AG?uch-Lutwin, MGrybo?, AS?oczy?ska, KP?kala, E?mudzki, PBucki, AKo?aczkowski, M?elaszczyk, DMarona, HWaszkielewicz, AM Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system. Bioorg Med Chem Lett 28:2039-2049 (2018) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM22875
Synonyms:
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol | Atarax | CHEMBL896 | Durrax | Hydroxyzine | Hydroxyzine Pamoate | Hydroxyzine, (R) | Orgatrax | Vistaril | med.21724, Compound 187
Type:
Small organic molecule
Emp. Form.:
C21H27ClN2O2
Mol. Mass.:
374.904
SMILES:
OCCOCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: