Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM82351
Substrate
n/a
Meas. Tech.
ChEMBL_1763031 (CHEMBL4198278)
Ki
56±n/a nM
Citation
 Dadashpour, S; Emami, S Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms. Eur J Med Chem 150:9-29 (2018) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM82351
Synonyms:
1-{[4-(substitutedphenyl/phenylethyl)piperazin1-yl]methyl}-3-methyl-1 H-indole, 3b
Type:
Small organic molecule
Emp. Form.:
C22H27N3
Mol. Mass.:
333.4699
SMILES:
Cc1cn(CN2CCN(CCc3ccccc3)CC2)c2ccccc12
Structure:
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