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Target
Prostacyclin synthase
Ligand
BDBM50022217
Substrate
n/a
Meas. Tech.
ChEBML_152778
IC50
>100000±n/a nM
Citation
 Cross, PE; Dickinson, RP; Parry, MJ; Randall, MJ Selective thromboxane synthetase inhibitors. 4. 2-(1H-imidazol-1-ylmethyl) carboxylic acids of benzo[b]furan, benzo[b]thiophene, indole, and naphthalene. J Med Chem 29:1643-50 (1986) [PubMed]  Article 
Target
Name:
Prostacyclin synthase
Synonyms:
CYP8 | CYP8A1 | PTGIS | PTGIS_HUMAN | Prostaglandin I2 synthase
Type:
PROTEIN
Mol. Mass.:
57109.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_157785
Residue:
500
Sequence:
MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP
  
Inhibitor
Name:
BDBM50022217
Synonyms:
2-Imidazol-1-ylmethyl-benzo[b]thiophene-5-carboxylic acid | CHEMBL46912
Type:
Small organic molecule
Emp. Form.:
C13H10N2O2S
Mol. Mass.:
258.296
SMILES:
OC(=O)c1ccc2sc(Cn3ccnc3)cc2c1
Structure:
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