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Target
TYR_PHOSPHATASE_2 domain-containing protein
Ligand
BDBM50459230
Substrate
n/a
Meas. Tech.
ChEMBL_1765861 (CHEMBL4201108)
IC50
1000±n/a nM
Citation
 Vickers, CF; Silva, APG; Chakraborty, A; Fernandez, P; Kurepina, N; Saville, C; Naranjo, Y; Pons, M; Schnettger, LS; Gutierrez, MG; Park, S; Kreiswith, BN; Perlin, DS; Thomas, EJ; Cavet, JS; Tabernero, L Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo. J Med Chem 61:8337-8352 (2018) [PubMed]  Article 
Target
Name:
TYR_PHOSPHATASE_2 domain-containing protein
Synonyms:
(PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB
Type:
Hydrolase
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50459230
Synonyms:
CHEMBL4215472
Type:
Small organic molecule
Emp. Form.:
C22H13ClN2O6
Mol. Mass.:
436.801
SMILES:
OC(=O)c1noc(c1-c1cccc(c1)-c1cc(Cl)c(O)c(c1)[N+]([O-])=O)-c1ccccc1
Structure:
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