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Target
Dual specificity protein phosphatase 3
Ligand
BDBM50459233
Substrate
n/a
Meas. Tech.
ChEMBL_1765859 (CHEMBL4201106)
IC50
12300±n/a nM
Citation
 Vickers, CF; Silva, APG; Chakraborty, A; Fernandez, P; Kurepina, N; Saville, C; Naranjo, Y; Pons, M; Schnettger, LS; Gutierrez, MG; Park, S; Kreiswith, BN; Perlin, DS; Thomas, EJ; Cavet, JS; Tabernero, L Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo. J Med Chem 61:8337-8352 (2018) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50459233
Synonyms:
CHEMBL4207543
Type:
Small organic molecule
Emp. Form.:
C22H13Cl2NO3
Mol. Mass.:
410.25
SMILES:
OC(=O)c1noc(c1-c1cccc(c1)-c1cc(Cl)cc(Cl)c1)-c1ccccc1
Structure:
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