Reaction Details Report a problem with these data
Target
Synaptic vesicular amine transporter
Ligand
BDBM50009057
Substrate
n/a
Meas. Tech.
ChEMBL_1766899 (CHEMBL4202146)
IC50
2740±n/a nM
Citation
 Provencher, BA; Eshleman, AJ; Johnson, RA; Shi, X; Kryatova, O; Nelson, J; Tian, J; Gonzalez, M; Meltzer, PC; Janowsky, A Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. J Med Chem 61:9121-9131 (2018) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Synaptic vesicular amine transporter | VAT2 | VMAT2_MOUSE | Vesicular amine transporter 2 | Vmat2
Type:
PROTEIN
Mol. Mass.:
55751.56
Organism:
Mus musculus
Description:
ChEMBL_118131
Residue:
517
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNTTEIQTARPALTASTSESFHSIFSYYNNSTVFTGNATGGLPGGESPKATTTQHTVTNTTVPPDCPSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIVVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIVFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNVQPYPVGDDEESESD
  
Inhibitor
Name:
BDBM50009057
Synonyms:
(R)Methyl-(1-methyl-2-phenyl-ethyl)-amine | METHAMPHETAMINE | METHAMPHETAMINE (+) | METHAMPHETAMINE (-) | Methyl-(1-methyl-2-phenyl-ethyl)-amine | Methyl-(1-methyl-2-phenyl-ethyl)-amine(methamphetamine)
Type:
Small organic molecule
Emp. Form.:
C10H15N
Mol. Mass.:
149.2328
SMILES:
CNC(C)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: