Reaction Details Report a problem with these data
Target
Glycine receptor subunit alpha-3
Ligand
BDBM50229711
Substrate
n/a
Meas. Tech.
ChEMBL_1767821 (CHEMBL4219933)
EC50
490±n/a nM
Citation
 Cioffi, CL Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain. J Med Chem 61:2652-2679 (2018) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-3
Synonyms:
GLRA3_MOUSE | Glra3 | Glycine receptor subunit alpha-3
Type:
PROTEIN
Mol. Mass.:
53719.15
Organism:
Mus musculus
Description:
ChEMBL_118157
Residue:
464
Sequence:
MAHVRHFRTLVSGFYFWEAALLLSLVATKETNSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDTDDEVRESRFSFTAYGMGPCLQAKDGVVPKGPNHAVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
  
Inhibitor
Name:
BDBM50229711
Synonyms:
CHEMBL4074873
Type:
Small organic molecule
Emp. Form.:
C19H17N3O4S
Mol. Mass.:
383.421
SMILES:
[H][C@@]12CN(C[C@]1([H])c1cnccc1N(C)C2=O)S(=O)(=O)c1ccc2occc2c1 |r|
Structure:
Search PDB for entries with ligand similarity: