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Target
Glucagon receptor
Ligand
BDBM50460584
Substrate
n/a
Meas. Tech.
ChEMBL_1769909 (CHEMBL4222021)
IC50
2380±n/a nM
Citation
 Shu, S; Dai, A; Wang, J; Wang, B; Feng, Y; Li, J; Cai, X; Yang, D; Ma, D; Wang, MW; Liu, H A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities. Bioorg Med Chem 26:1896-1908 (2018) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50460584
Synonyms:
CHEMBL4227967
Type:
Small organic molecule
Emp. Form.:
C31H25Cl2N3O3
Mol. Mass.:
558.455
SMILES:
Cc1c(nn(Cc2ccc(cc2)C(=O)NCCC(O)=O)c1-c1cccc2ccccc12)-c1cc(Cl)cc(Cl)c1 |(33.03,-25.16,;31.57,-25.64,;30.32,-24.74,;29.08,-25.64,;29.56,-27.1,;28.79,-28.43,;27.25,-28.43,;26.48,-27.1,;24.94,-27.1,;24.18,-28.43,;24.94,-29.77,;26.48,-29.77,;22.64,-28.43,;21.86,-27.1,;21.86,-29.77,;20.32,-29.77,;19.56,-28.43,;18.02,-28.43,;17.24,-27.1,;17.24,-29.77,;31.1,-27.1,;32,-28.35,;33.54,-28.18,;34.44,-29.42,;33.82,-30.83,;32.29,-31,;31.67,-32.41,;30.13,-32.57,;29.23,-31.32,;29.85,-29.92,;31.38,-29.75,;30.32,-23.2,;31.65,-22.43,;31.65,-20.88,;32.98,-20.11,;30.31,-20.12,;28.99,-20.89,;27.65,-20.13,;28.99,-22.43,)|
Structure:
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