Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50460579
Substrate
n/a
Meas. Tech.
ChEBML_1769908
IC50
570±n/a nM
Citation
 Shu, S; Dai, A; Wang, J; Wang, B; Feng, Y; Li, J; Cai, X; Yang, D; Ma, D; Wang, MW; Liu, H A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities. Bioorg Med Chem 26:1896-1908 (2018) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50460579
Synonyms:
CHEMBL4226770
Type:
Small organic molecule
Emp. Form.:
C32H27Cl2N3O3
Mol. Mass.:
572.481
SMILES:
CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(c(C)c1-c1cccc2ccccc12)-c1cc(Cl)cc(Cl)c1 |(34.44,-19.76,;34.76,-21.26,;33.61,-22.3,;32.15,-21.82,;31,-22.85,;31.32,-24.36,;32.79,-24.83,;33.93,-23.8,;30.18,-25.39,;28.71,-24.91,;30.5,-26.89,;29.35,-27.92,;29.67,-29.43,;28.53,-30.46,;27.07,-29.98,;28.85,-31.97,;36.22,-21.74,;36.7,-23.21,;38.24,-23.21,;38.71,-21.74,;40.18,-21.26,;37.47,-20.84,;37.47,-19.3,;36.13,-18.53,;36.13,-16.99,;37.47,-16.22,;38.8,-16.99,;40.13,-16.22,;41.47,-16.99,;41.47,-18.53,;40.13,-19.3,;38.8,-18.53,;39.14,-24.45,;38.52,-25.86,;39.42,-27.1,;38.79,-28.51,;40.95,-26.94,;41.58,-25.54,;43.11,-25.38,;40.67,-24.29,)|
Structure:
Search PDB for entries with ligand similarity: