Reaction Details
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Glucagon receptor
Ligand
BDBM50460581
Substrate
n/a
Meas. Tech.
ChEMBL_1769908 (CHEMBL4222020)
IC50
310±n/a nM
Citation
Shu, S; Dai, A; Wang, J; Wang, B; Feng, Y; Li, J; Cai, X; Yang, D; Ma, D; Wang, MW; Liu, H A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities. Bioorg Med Chem 26:1896-1908 (2018) [PubMed] Article More Info.:
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
Inhibitor
Name:
BDBM50460581
Synonyms:
CHEMBL4227634
Type:
Small organic molecule
Emp. Form.:
C34H29Cl2N3O3
Mol. Mass.:
598.518
SMILES:
CC(c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(c(C)c1-c1ccccc1-c1ccccc1)-c1cc(Cl)cc(Cl)c1 |(39.58,-31.15,;38.81,-29.82,;37.27,-29.82,;36.5,-31.15,;34.96,-31.15,;34.19,-29.82,;34.96,-28.48,;36.5,-28.48,;32.65,-29.82,;31.88,-31.15,;31.88,-28.48,;30.34,-28.48,;29.57,-29.82,;28.03,-29.82,;27.26,-31.15,;27.26,-28.48,;39.58,-28.48,;38.95,-27.08,;40.1,-26.05,;41.43,-26.82,;42.84,-26.19,;41.11,-28.32,;42.45,-29.81,;41.97,-31.27,;43,-32.42,;44.51,-32.1,;44.98,-30.63,;43.95,-29.49,;44.72,-28.15,;46.26,-28.15,;47.03,-26.82,;46.26,-25.49,;44.72,-25.49,;43.95,-26.82,;39.94,-24.52,;41.18,-23.61,;41.02,-22.08,;42.26,-21.18,;39.61,-21.46,;38.37,-22.36,;36.96,-21.73,;38.53,-23.89,)|
Structure:
