Reaction Details Report a problem with these data
Target
Sterol O-acyltransferase 2
Ligand
BDBM50360305
Substrate
n/a
Meas. Tech.
ChEMBL_1771368 (CHEMBL4223480)
IC50
>20000±n/a nM
Citation
 Kapojos, MM; Abdjul, DB; Yamazaki, H; Ohshiro, T; Rotinsulu, H; Wewengkang, DS; Sumilat, DA; Tomoda, H; Namikoshi, M; Uchida, R Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp. Bioorg Med Chem Lett 28:1911-1914 (2018) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 2
Synonyms:
ACAT-2 | ACAT2 | Acyl-coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | SOAT2 | SOAT2_CHLAE | Sterol O-acyltransferase 2
Type:
PROTEIN
Mol. Mass.:
60426.29
Organism:
Chlorocebus aethiops
Description:
ChEMBL_116979
Residue:
526
Sequence:
MEPGGARLRLQRTEGPGGEREHQPCRDGNTETHRAPDLVKWTRHMEAVKAQLLEQAQGQLRELLDRAMWEAIQSYPSQDKPPPLPPPDSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARPGARGTWTLGAGLGCALLAAHALVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYIRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGAQARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQHTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQTTFWGLVTPRSWSCHT
  
Inhibitor
Name:
BDBM50360305
Synonyms:
CHEMBL409855 | US9149492, Beauveriolide III
Type:
Small organic molecule
Emp. Form.:
C27H41N3O5
Mol. Mass.:
487.6315
SMILES:
CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 |r|
Structure:
Search PDB for entries with ligand similarity: