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Target
Serine palmitoyltransferase 2
Ligand
BDBM50461642
Substrate
n/a
Meas. Tech.
ChEMBL_1771688 (CHEMBL4223800)
IC50
2800±n/a nM
Citation
 Kojima, T; Asano, Y; Kurasawa, O; Hirata, Y; Iwamura, N; Wong, TT; Saito, B; Tanaka, Y; Arai, R; Yonemori, K; Miyamoto, Y; Sagiya, Y; Yaguchi, M; Shibata, S; Mizutani, A; Sano, O; Adachi, R; Satomi, Y; Hirayama, M; Aoyama, K; Hiura, Y; Kiba, A; Kitamura, S; Imamura, S Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents. Bioorg Med Chem 26:2452-2465 (2018) [PubMed]  Article 
Target
Name:
Serine palmitoyltransferase 2
Synonyms:
KIAA0526 | LCB 2 | LCB2 | LCB2a | Long chain base biosynthesis protein 2 | Long chain base biosynthesis protein 2a | SPT 2 | SPTC2_HUMAN | SPTLC2 | Serine-palmitoyl-CoA transferase 2
Type:
PROTEIN
Mol. Mass.:
62932.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_660504
Residue:
562
Sequence:
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED
  
Inhibitor
Name:
BDBM50461642
Synonyms:
CHEMBL4229268
Type:
Small organic molecule
Emp. Form.:
C25H26F3N5O5
Mol. Mass.:
533.4996
SMILES:
COc1cc(cnc1OC)C(=O)N1CC[C@@H](NC(=O)c2ccccc2OC(F)(F)F)c2c1cnn2C(C)C |r|
Structure:
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