Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50025103
Substrate
n/a
Meas. Tech.
ChEMBL_52220 (CHEMBL666689)
Ki
400±n/a nM
Citation
 Young, RN; Bélanger, P; Champion, E; DeHaven, RN; Denis, D; Ford-Hutchinson, AW; Fortin, R; Frenette, R; Gauthier, JY; Gillard, J Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4. J Med Chem 29:1573-6 (1986) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50025103
Synonyms:
CHEMBL41301 | Sodium; 4-{4-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-hydroxy-3-methyl-butyrate
Type:
Small organic molecule
Emp. Form.:
C25H31O6S
Mol. Mass.:
459.576
SMILES:
CCCc1c(O)c(ccc1OCCCSc1ccc(cc1)C(O)[C@@H](C)CC([O-])=O)C(C)=O
Structure:
Search PDB for entries with ligand similarity: