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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50466301
Substrate
n/a
Meas. Tech.
ChEMBL_1792740 (CHEMBL4264659)
IC50
1.9±n/a nM
Citation
 Liu, X; Zhang, Y; Huang, W; Luo, J; Li, Y; Tan, W; Zhang, A Development of high potent and selective Bcl-2 inhibitors bearing the structural elements of natural product artemisinin. Eur J Med Chem 159:149-165 (2018) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50466301
Synonyms:
CHEMBL4284025
Type:
Small organic molecule
Emp. Form.:
C48H61N7O12S
Mol. Mass.:
960.103
SMILES:
[H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@@]4(C)OO[C@@]13[C@]([H])(OC(OCCNC1CCN(CC1)c1ccc(C(=O)NS(=O)(=O)c3ccc(NCC5CCOCC5)c(c3)[N+]([O-])=O)c(Oc3cnc5[nH]ccc5c3)c1)[C@@H]2C)O4 |r|
Structure:
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