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Target
Sialidase B
Ligand
BDBM50331692
Substrate
n/a
Meas. Tech.
ChEMBL_1793222 (CHEMBL4265141)
IC50
>1000000±n/a nM
Citation
 Slack, TJ; Li, W; Shi, D; McArthur, JB; Zhao, G; Li, Y; Xiao, A; Khedri, Z; Yu, H; Liu, Y; Chen, X Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. Bioorg Med Chem 26:5751-5757 (2018) [PubMed]  Article 
Target
Name:
Sialidase B
Synonyms:
3.2.1.18 | ERS019367_01945 | ERS020827_03579 | ERS020831_00920 | ERS020835_02022 | ERS021057_01882 | ERS044004_02586 | ERS232497_01500 | ERS232508_02024 | NCTC12140_01089 | SAMEA104035134_02026 | SAMEA104035600_00945 | SAMEA104035607_00843 | SAMEA104035661_01516 | SAMEA104035685_00392 | SAMEA104035780_00844 | SAMEA104035793_00570 | SAMEA104035969_00724 | SAMEA104038592_00808 | SAMEA104038601_00646 | SAMEA104154734_00994 | SAMEA104154956_00670 | SAMEA104155010_00837 | SAMEA104155071_00927 | SAMEA104155114_01026 | SAMEA104155120_00646 | SAMEA2203781_01468 | SAMEA2203811_01877 | SAMEA2203858_01191 | SAMEA2203862_00684 | SAMEA2203875_01711 | SAMEA2203917_00759 | SAMEA2204024_01263 | SAMEA2204025_01058 | SAMEA2298232_00545 | SAMEA2335946_01921 | SAMEA2335950_01342 | SAMEA2335953_00522 | SAMEA2335963_00913 | SAMEA2335973_00797 | SAMEA2335986_00516 | SAMEA2434685_00773 | SAMEA2467564_01024 | SAMEA2521548_00160 | SAMEA2521588_01906 | SAMEA2521612_00959 | SAMEA2521663_01097 | SAMEA2627268_00595 | SAMEA2696318_02138 | SAMEA2696453_01515 | SAMEA2796487_00122 | SAMEA2796704_00864 | SAMEA2796719_00497 | SAMEA2814217_00122 | SAMEA3175895_00461 | SAMEA3176147_02084 | SAMEA3207192_00062 | SAMEA3232645_00606 | SAMEA3309691_02132 | SAMEA3309728_02130 | SAMEA3309780_02133 | SAMEA3309798_02172 | SAMEA3309811_02081 | SAMEA3309816_02188 | SAMEA3353204_02017 | SAMEA3353605_01701 | SAMEA3354337_01473 | SAMEA3381403_01265 | SAMEA3381572_01956 | SAMEA3381590_01962 | SAMEA3381642_01980 | SAMEA3388883_01020 | SAMEA3389847_00274 | SAMEA3506052_02132 | SAMEA3714202_00387 | SAMEA4388065_01009 | SAMEA4388224_01628 | SAMEA4707825_00570 | SAMEA4707856_00778 | SAMEA4707909_00935 | Sialidase B | nanB_1 | nanB_2 | nanB_3 | nanC
Type:
PROTEIN
Mol. Mass.:
82442.94
Organism:
Streptococcus pneumoniae
Description:
ChEMBL_117767
Residue:
740
Sequence:
MKKNIKQYVTLGTVVVLSAFVANSVAAQETETSEVSTPKLVQPVAPTTPISEVQPTSDNSSEVTVQPRTVETTVKDPSSTAEETPVLEKNNVTLTGGGENVTKELKDKFTSGDFTVVIKYNQSSEKGLQALFGISNSKPGQQNSYVDVFLRDNGELGMEARDTSSNKNNLVSRPASVWGKYKQEAVTNTVAVVADSVKKTYSLYANGTKVVEKKVDNFLNIKDIKGIDYYMLGGVKRAGKTAFGFNGTLENIKFFNSALDEETVKKMTTNAVTGHLIYTANDTTGSNYFRIPVLYTFSNGRVFSSIDARYGGTHDFLNKINIATSYSDDNGKTWTKPKLTLAFDDFAPVPLEWPREVGGRDLQISGGATYIDSVIVEKKNKQVLMFADVMPAGVSFREATRKDSGYKQIDGNYYLKLRKQGDTDYNYTIRENGTVYDDRTNRPTEFSVDKNFGIKQNGNYLTVEQYSVSFENNKKTEYRNGTKVHMNIFYKDALFKVVPTNYIAYISSNDHGESWSAPTLLPPIMGLNRNAPYLGPGRGIIESSTGRILIPSYTGKESAFIYSDDNGASWKVKVVPLPSSWSAEAQFVELSPGVIQAYMRTNNGKIAYLTSKDAGTTWSAPEYLKFVSNPSYGTQLSIINYSQLIDGKKAVILSTPNSTNGRKHGQIWIGLINDDNTIDWRYHHDVDYSNYGYSYSTLTELPNHEIGLMFEKFDSWSRNELHMKNVVPYITFKIEDLKKN
  
Inhibitor
Name:
BDBM50331692
Synonyms:
(2R,3R,4S)-3-acetamido-2-((1R,2R)-3-azido-1,2-dihydroxypropyl)-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylate | CHEMBL1289311
Type:
Small organic molecule
Emp. Form.:
C11H16N4O7
Mol. Mass.:
316.2673
SMILES:
CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CN=[N+]=[N-])C(O)=O |r,c:7|
Structure:
Search PDB for entries with ligand similarity: