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Target
Urease subunit beta
Ligand
BDBM50467080
Substrate
n/a
Meas. Tech.
ChEMBL_1794866 (CHEMBL4266983)
IC50
8210±n/a nM
Citation
 Yang, YS; Su, MM; Zhang, XP; Liu, QX; He, ZX; Xu, C; Zhu, HL Developing potential Helicobacter pylori urease inhibitors from novel oxoindoline derivatives: Synthesis, biological evaluation and in silico study. Bioorg Med Chem Lett 28:3182-3186 (2018) [PubMed]  Article 
Target
Name:
Urease subunit beta
Synonyms:
3.5.1.5 | Urea amidohydrolase subunit beta | Urease subunit beta | ureB
Type:
PROTEIN
Mol. Mass.:
61708.53
Organism:
Helicobacter pylori
Description:
ChEMBL_100923
Residue:
569
Sequence:
MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGITTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSKAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPATKVSLAQLFSIF
  
Inhibitor
Name:
BDBM50467080
Synonyms:
CHEMBL4282631
Type:
Small organic molecule
Emp. Form.:
C21H21N3O3
Mol. Mass.:
363.4097
SMILES:
[#6]-[#8]-c1cccc(c1)-[#6](=O)-[#7]\[#7]=[#6]-1\[#6](=O)-[#7](-[#6]\[#6]=[#6](\[#6])-[#6])-c2ccccc-12
Structure:
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