Reaction Details Report a problem with these data
Target
Carbonic anhydrase 12
Ligand
BDBM50103514
Substrate
n/a
Meas. Tech.
ChEMBL_1797476 (CHEMBL4269593)
Ki
45±n/a nM
Citation
 Angeli, A; Ferraroni, M; Supuran, CT Famotidine, an Antiulcer Agent, Strongly Inhibits  ACS Med Chem Lett 9:1035-1038 (2018) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50103514
Synonyms:
CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid | Pepcid Ac | Pepcid Rpd
Type:
Small organic molecule
Emp. Form.:
C8H15N7O2S3
Mol. Mass.:
337.445
SMILES:
NC(=N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
Structure:
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