Reaction Details Report a problem with these data
Target
Somatostatin receptor type 5
Ligand
BDBM50468131
Substrate
n/a
Meas. Tech.
ChEMBL_1798124 (CHEMBL4270241)
IC50
6.1±n/a nM
Citation
 Liu, W; Shao, PP; Liang, GB; Bawiec, J; He, J; Aster, SD; Wu, M; Chicchi, G; Wang, J; Tsao, KL; Shang, J; Salituro, G; Zhou, YP; Li, C; Akiyama, TE; Metzger, DE; Murphy, BA; Howard, AD; Weber, AE; Duffy, JL Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition. ACS Med Chem Lett 9:1082-1087 (2018) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 5
Synonyms:
SS-5-R | SS5-R | SS5R | SSR5_MOUSE | Smstr5 | Somatostatin receptor | Somatostatin receptor 5 | Somatostatin receptor type 5 | Sstr5
Type:
PROTEIN
Mol. Mass.:
40022.97
Organism:
Mus musculus
Description:
ChEMBL_833921
Residue:
362
Sequence:
MEPLSLTSTPSWNASAASSSSHNWSLVDPVSPMGARAVLVPVLYLLVCTVGLGGNTLVIYVVLRYAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSYWPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKLASAAVWVFSLLMSLPLLVFADVQEGWGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAGMRVGSSRRRRSERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPEEPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKALCLRRGYGVEDADAIEPRPDKSGRPQTTLPTRSCEANGLMQTSRL
  
Inhibitor
Name:
BDBM50468131
Synonyms:
CHEMBL4277106
Type:
Small organic molecule
Emp. Form.:
C32H34FN3O5
Mol. Mass.:
559.6279
SMILES:
[H][C@@]12CCN(Cc3cc(OCC)c(c(OCC)c3)-c3ccc(F)cc3)[C@]1([H])CCC2Nc1nc2ccc(cc2o1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: