Reaction Details Report a problem with these data
Target
Fatty acid-binding protein, adipocyte
Ligand
BDBM50468378
Substrate
n/a
Meas. Tech.
ChEMBL_1799370 (CHEMBL4271662)
Ki
7380±n/a nM
Citation
 Gao, DD; Dou, HX; Su, HX; Zhang, MM; Wang, T; Liu, QF; Cai, HY; Ding, HP; Yang, Z; Zhu, WL; Xu, YC; Wang, HY; Li, YX From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4. Eur J Med Chem 154:44-59 (2018) [PubMed]  Article 
Target
Name:
Fatty acid-binding protein, adipocyte
Synonyms:
A-FABP | AFABP | ALBP | Adipocyte lipid-binding protein | FABP4 | FABP4_HUMAN | Fatty acid binding protein adipocyte | Fatty acid-binding protein 4 | Fatty acid-binding protein 4 (FABP4)
Type:
Enzyme
Mol. Mass.:
14719.23
Organism:
Homo sapiens (Human)
Description:
P15090
Residue:
132
Sequence:
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA
  
Inhibitor
Name:
BDBM50468378
Synonyms:
CHEMBL4294166
Type:
Small organic molecule
Emp. Form.:
C18H13F2NO5S
Mol. Mass.:
393.361
SMILES:
COc1ccc(c2ccccc12)S(=O)(=O)Nc1ccc(F)c(C(O)=O)c1F
Structure:
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