Reaction Details Report a problem with these data
Target
Prohibitin-2
Ligand
BDBM50468573
Substrate
n/a
Meas. Tech.
ChEMBL_1800026 (CHEMBL4272318)
EC50
2500±n/a nM
Citation
 Djehal, A; Krayem, M; Najem, A; Hammoud, H; Cresteil, T; Nebigil, CG; Wang, D; Yu, P; Bentouhami, E; Ghanem, GE; Désaubry, L Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells. Eur J Med Chem 155:880-888 (2018) [PubMed]  Article 
Target
Name:
Prohibitin-2
Synonyms:
B-cell receptor-associated protein BAP37 | Bap | Bcap37 | PHB2_MOUSE | Phb2 | Prohibitin-2 | Rea | Repressor of estrogen receptor activity
Type:
PROTEIN
Mol. Mass.:
33309.07
Organism:
Mus musculus
Description:
ChEMBL_117904
Residue:
299
Sequence:
MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIKGKK
  
Inhibitor
Name:
BDBM50468573
Synonyms:
CHEMBL4293894
Type:
Small organic molecule
Emp. Form.:
C22H22F6N6O3
Mol. Mass.:
532.4389
SMILES:
NCCOCCOCCNc1nc(NCc2cccc(F)c2)nc(Oc2c(F)c(F)c(F)c(F)c2F)n1
Structure:
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