Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM354740
Substrate
n/a
Meas. Tech.
ChEMBL_1803969 (CHEMBL4276261)
EC50
457±n/a nM
Citation
 Zhang, YM; Greco, MN; Macielag, MJ; Teleha, CA; DesJarlais, RL; Tang, Y; Ho, G; Hou, C; Chen, C; Zhao, S; Kauffman, J; Camacho, R; Qi, J; Murray, W; Demarest, K; Leonard, J 6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB J Med Chem 61:10276-10298 (2018) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM354740
Synonyms:
US9815790, 2
Type:
Small organic molecule
Emp. Form.:
C43H54Cl2F3N3O10S
Mol. Mass.:
932.869
SMILES:
COCCOCCOCCOCCOCCOCCOCCOc1cc(NC2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(ccc2n1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Structure:
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