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Target
Cytochrome P450 2D6
Ligand
BDBM208270
Substrate
n/a
Meas. Tech.
ChEMBL_1803978 (CHEMBL4276270)
IC50
>10000±n/a nM
Citation
 Zhang, YM; Greco, MN; Macielag, MJ; Teleha, CA; DesJarlais, RL; Tang, Y; Ho, G; Hou, C; Chen, C; Zhao, S; Kauffman, J; Camacho, R; Qi, J; Murray, W; Demarest, K; Leonard, J 6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB J Med Chem 61:10276-10298 (2018) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM208270
Synonyms:
US9266835, 41
Type:
Small organic molecule
Emp. Form.:
C25H22ClF3N4O3S2
Mol. Mass.:
583.045
SMILES:
FC(F)(F)S(=O)(=O)N1CCC(CC1)Nc1cc(=O)[nH]c2ccc(cc12)C(c1nccs1)c1ccc(Cl)cc1
Structure:
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