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Target
mRNA cap guanine-N7 methyltransferase
Ligand
BDBM50470562
Substrate
n/a
Meas. Tech.
ChEMBL_1803165 (CHEMBL4275457)
Ki
>50000±n/a nM
Citation
 Tao, Z; Cao, R; Yan, Y; Huang, G; Lv, K; Li, W; Geng, Y; Zhao, L; Wang, A; He, Q; Yang, J; Fan, S; Huang, M; Guo, H; Zhong, W; Liu, M Design, synthesis and in vitro anti-Zika virus evaluation of novel Sinefungin derivatives. Eur J Med Chem 157:994-1004 (2018) [PubMed]  Article 
Target
Name:
mRNA cap guanine-N7 methyltransferase
Synonyms:
2.1.1.56 | KIAA0398 | MCES_HUMAN | RG7MT1 | RNMT | hCMT1 | hMet | hcm1p | mRNA (guanine-N(7)-)-methyltransferase | mRNA cap guanine-N7 methyltransferase | mRNA cap methyltransferase
Type:
PROTEIN
Mol. Mass.:
54843.48
Organism:
Homo sapiens
Description:
ChEMBL_117907
Residue:
476
Sequence:
MANSAKAEEYEKMSLEQAKASVNSETESSFNINENTTASGTGLSEKTSVCRQVDIARKRKEFEDDLVKESSSCGKDTPSKKRKLDPEIVPEEKDCGDAEGNSKKRKRETEDVPKDKSSTGDGTQNKRKIALEDVPEKQKNLEEGHSSTVAAHYNELQEVGLEKRSQSRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQALEPYPANESSKLVSEKVDDYEHAAKYMKNSQVRLPLGTLSKSEWEATSIYLVFAFEKQQ
  
Inhibitor
Name:
BDBM50470562
Synonyms:
CHEMBL1230055
Type:
Small organic molecule
Emp. Form.:
C21H25ClN6O5S
Mol. Mass.:
508.978
SMILES:
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(Cl)c3)ncnc12)C(O)=O |r|
Structure:
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