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Target
Sodium/hydrogen exchanger 3
Ligand
BDBM50471148
Substrate
n/a
Meas. Tech.
ChEMBL_164985 (CHEMBL774080)
IC50
14±n/a nM
Citation
 Baumgarth, M; Beier, N; Gericke, R (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem 40:2017-34 (1997) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 3
Synonyms:
NHE-3 | NHE3 | Na(+)/H(+) exchanger 3 | SL9A3_RABIT | SLC9A3 | Sodium/hydrogen exchanger 3 | Solute carrier family 9 member 3
Type:
PROTEIN
Mol. Mass.:
92760.60
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_104865
Residue:
832
Sequence:
MSGRGGCGPCWGLLLALVLALGALPWTQGAEQEHHDEIQGFQIVTFKWHHVQDPYIIALWVLVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVLAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFSNLGSILLYAVVGTVWNAATTGLSLYGVFLSGIMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFQSFVTLGGDKVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRVIEPGFVFIISYLSYLTSEMLSLSSILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPLIWTWNTAFVLLTLLFVSVFRAIGVVLQTWLLNRYRMVQLELIDQVVMSYGGLRGAVAFALVALLDGNKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWANFDRRFLSKLLMRQSAQKSRDRILNVFHELNLKDAISYVTEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYLLRESASAVCLDMQSLEQRRRSVRDAEDVITHHTLQQYLYKPRQEYKHLYSRHVLSPSEDEKQDKEIFHRTMRKRLESFKSAKLGLGQSKKATKHKRERERAQKRRNSSVPNGKLPLDSPAYGLTLKERELELSDPEEAPDYYEAEKMSGGIEFLASVTKDTTSDSPAGIDNPVFSPDEDLAPSLLARVPPWLSPGEAVVPSQRARVQIPYSPGNFRRLAPFRLSNKSVDSFLLAEDGAEHPESTHM
  
Inhibitor
Name:
BDBM50471148
Synonyms:
CHEMBL418505
Type:
Small organic molecule
Emp. Form.:
C16H16ClN3O3S2
Mol. Mass.:
397.9
SMILES:
[#6]-c1cc(-[#16]-c2ccccc2Cl)c(cc1-[#6](=O)\[#7]=[#6](/[#7])-[#7])S([#6])(=O)=O
Structure:
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