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Target
Glycylpeptide N-tetradecanoyltransferase 1/2
Ligand
BDBM50059428
Substrate
n/a
Meas. Tech.
ChEMBL_141179 (CHEMBL750676)
IC50
130±n/a nM
Citation
 Devadas, B; Freeman, SK; Zupec, ME; Lu, HF; Nagarajan, SR; Kishore, NS; Lodge, JK; Kuneman, DW; McWherter, CA; Vinjamoori, DV; Getman, DP; Gordon, JI; Sikorski, JA Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity. J Med Chem 40:2609-25 (1997) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1/2
Synonyms:
Peptide N-myristoyltransferase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 141178
Components:
This complex has 2 components.
Component 1
Name:
Glycylpeptide N-tetradecanoyltransferase 2
Synonyms:
Glycylpeptide N-tetradecanoyltransferase 2 | Myristoyl-CoA:protein N-myristoyltransferase 2 | NMT 2 | NMT2 | NMT2_HUMAN | Peptide N-myristoyltransferase 2 | Type II N-myristoyltransferase
Type:
PROTEIN
Mol. Mass.:
56986.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435042
Residue:
498
Sequence:
MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ
  
Component 2
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Homo sapiens (Human)
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM50059428
Synonyms:
(S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-imidazol-1-yl)-butyl]-phenyl}-pentanoylamino)-propionylamino]-hexanoic acid (2-cyclohexyl-ethyl)-amide | CHEMBL291811
Type:
Small organic molecule
Emp. Form.:
C36H58N6O4
Mol. Mass.:
638.8835
SMILES:
CCCC(C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC1CCCCC1)c1ccc(CCCCn2ccnc2C)cc1
Structure:
Search PDB for entries with ligand similarity: