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Target
Sodium/hydrogen exchanger 3
Ligand
BDBM50058715
Substrate
n/a
Meas. Tech.
ChEMBL_202731 (CHEMBL809059)
IC50
8.0±n/a nM
Citation
 Baumgarth, M; Beier, N; Gericke, R Bicyclic acylguanidine Na+/H+ antiporter inhibitors. J Med Chem 41:3736-47 (1998) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 3
Synonyms:
NHE-3 | NHE3 | Na(+)/H(+) exchanger 3 | SL9A3_RABIT | SLC9A3 | Sodium/hydrogen exchanger 3 | Solute carrier family 9 member 3
Type:
PROTEIN
Mol. Mass.:
92760.60
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_104865
Residue:
832
Sequence:
MSGRGGCGPCWGLLLALVLALGALPWTQGAEQEHHDEIQGFQIVTFKWHHVQDPYIIALWVLVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVLAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFSNLGSILLYAVVGTVWNAATTGLSLYGVFLSGIMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFQSFVTLGGDKVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRVIEPGFVFIISYLSYLTSEMLSLSSILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPLIWTWNTAFVLLTLLFVSVFRAIGVVLQTWLLNRYRMVQLELIDQVVMSYGGLRGAVAFALVALLDGNKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWANFDRRFLSKLLMRQSAQKSRDRILNVFHELNLKDAISYVTEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYLLRESASAVCLDMQSLEQRRRSVRDAEDVITHHTLQQYLYKPRQEYKHLYSRHVLSPSEDEKQDKEIFHRTMRKRLESFKSAKLGLGQSKKATKHKRERERAQKRRNSSVPNGKLPLDSPAYGLTLKERELELSDPEEAPDYYEAEKMSGGIEFLASVTKDTTSDSPAGIDNPVFSPDEDLAPSLLARVPPWLSPGEAVVPSQRARVQIPYSPGNFRRLAPFRLSNKSVDSFLLAEDGAEHPESTHM
  
Inhibitor
Name:
BDBM50058715
Synonyms:
CHEMBL64360 | EMD-96785 | ENIPORIDE | N-(5-Methanesulfonyl-2-methyl-4-pyrrol-1-yl-benzoyl)-guanidine | N-(5-Methanesulfonyl-2-methyl-4-pyrrol-1-yl-benzoyl)-guanidine (Eniporide, EMD-96-875) | N-(diaminomethylene)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C14H16N4O3S
Mol. Mass.:
320.367
SMILES:
Cc1cc(c(cc1C(=O)NC(N)=N)S(C)(=O)=O)-n1cccc1
Structure:
Search PDB for entries with ligand similarity: