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Target
Mitogen-activated protein kinase 13
Ligand
BDBM50473623
Substrate
n/a
Meas. Tech.
ChEMBL_124318 (CHEMBL732626)
IC50
4.0±n/a nM
Citation
 McKenna, JM; Halley, F; Souness, JE; McLay, IM; Pickett, SD; Collis, AJ; Page, K; Ahmed, I An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors. J Med Chem 45:2173-84 (2002) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 13
Synonyms:
MAP kinase 13 | MAP kinase p38 delta | MAPK 13 | MK13_MOUSE | Mapk13 | Mitogen-activated protein kinase 13 | Mitogen-activated protein kinase p38 delta | Serk4 | Stress-activated protein kinase 4
Type:
PROTEIN
Mol. Mass.:
42081.17
Organism:
Mus musculus
Description:
ChEMBL_105000
Residue:
366
Sequence:
MSLTRKRGFYKQDINKTAWELPKTYLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMGMEFSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFFEPFRDPEEETEAQQPFDDALEHEKLSVDEWKQHIYKEISNFSPIARKDSRRRSGMKLQ
  
Inhibitor
Name:
BDBM50473623
Synonyms:
CHEMBL309802 | RPR-238778
Type:
Small organic molecule
Emp. Form.:
C27H28FN7O3
Mol. Mass.:
517.5547
SMILES:
CN(C)C(=O)[C@@]1(C)CO[C@@H](OC1)c1nc(c([nH]1)-c1ccnc(NCc2ccccn2)n1)-c1ccc(F)cc1 |wU:9.12,5.5,wD:5.4,(19.11,-7.82,;18.34,-6.49,;19.11,-5.14,;16.8,-6.47,;16.03,-7.82,;16.04,-5.16,;16.8,-3.81,;15.28,-3.83,;13.74,-3.81,;12.98,-5.14,;13.74,-6.47,;15.27,-6.47,;11.44,-5.14,;10.53,-6.39,;9.06,-5.91,;9.08,-4.37,;10.55,-3.9,;7.75,-3.59,;7.75,-2.04,;6.4,-1.27,;5.07,-2.04,;5.07,-3.59,;3.74,-4.36,;2.41,-3.59,;1.07,-4.36,;-.26,-3.58,;-1.59,-4.35,;-1.6,-5.89,;-.25,-6.66,;1.08,-5.89,;6.4,-4.36,;7.82,-6.8,;6.42,-6.17,;5.16,-7.05,;5.33,-8.59,;3.97,-9.36,;6.74,-9.22,;7.98,-8.33,)|
Structure:
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