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Target
Mitogen-activated protein kinase 13
Ligand
BDBM50473627
Substrate
n/a
Meas. Tech.
ChEMBL_124318 (CHEMBL732626)
IC50
6.0±n/a nM
Citation
 McKenna, JM; Halley, F; Souness, JE; McLay, IM; Pickett, SD; Collis, AJ; Page, K; Ahmed, I An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors. J Med Chem 45:2173-84 (2002) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 13
Synonyms:
MAP kinase 13 | MAP kinase p38 delta | MAPK 13 | MK13_MOUSE | Mapk13 | Mitogen-activated protein kinase 13 | Mitogen-activated protein kinase p38 delta | Serk4 | Stress-activated protein kinase 4
Type:
PROTEIN
Mol. Mass.:
42081.17
Organism:
Mus musculus
Description:
ChEMBL_105000
Residue:
366
Sequence:
MSLTRKRGFYKQDINKTAWELPKTYLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMGMEFSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFFEPFRDPEEETEAQQPFDDALEHEKLSVDEWKQHIYKEISNFSPIARKDSRRRSGMKLQ
  
Inhibitor
Name:
BDBM50473627
Synonyms:
CHEMBL308203 | RPR-239939
Type:
Small organic molecule
Emp. Form.:
C26H33FN6O4
Mol. Mass.:
512.5764
SMILES:
CCCNC(=O)[C@@]1(C)CO[C@@H](OC1)c1nc(c([nH]1)-c1ccnc(NCCCOC)n1)-c1ccc(F)cc1 |wU:10.13,6.6,wD:6.5,(26.03,-17.02,;25.26,-15.68,;23.72,-15.68,;22.96,-14.34,;21.42,-14.34,;20.64,-15.67,;20.66,-13.01,;21.42,-11.67,;19.89,-11.68,;18.37,-11.67,;17.6,-13,;18.37,-14.33,;19.89,-14.33,;16.06,-13,;15.14,-14.24,;13.68,-13.75,;13.68,-12.21,;15.15,-11.75,;12.35,-11.44,;12.35,-9.89,;11.02,-9.12,;9.69,-9.89,;9.69,-11.44,;8.35,-12.21,;7.02,-11.44,;5.68,-12.21,;4.35,-11.44,;3.02,-12.2,;1.69,-11.43,;11.02,-12.21,;12.44,-14.65,;12.59,-16.18,;11.35,-17.08,;9.94,-16.45,;8.6,-17.21,;9.79,-14.91,;11.04,-14.01,)|
Structure:
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