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Target
Histamine H3 receptor
Ligand
BDBM50127607
Substrate
n/a
Meas. Tech.
ChEMBL_83663 (CHEMBL694892)
EC50
58±n/a nM
Citation
 Kitbunnadaj, R; Zuiderveld, OP; De Esch, IJ; Vollinga, RC; Bakker, R; Lutz, M; Spek, AL; Cavoy, E; Deltent, MF; Menge, WM; Timmerman, H; Leurs, R Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists. J Med Chem 46:5445-57 (2003) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50127607
Synonyms:
(1R,2R)-2-(1H-Imidazol-4-yl)-cyclopropylamine | (1R,2R)-2-(3H-Imidazol-4-yl)-cyclopropylamine | 2-(1H-Imidazol-4-yl)-cyclopropylamine | CHEMBL13559 | VUF-5296
Type:
Small organic molecule
Emp. Form.:
C6H9N3
Mol. Mass.:
123.1558
SMILES:
N[C@@H]1C[C@H]1c1cnc[nH]1
Structure:
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