Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50475335
Substrate
n/a
Meas. Tech.
ChEMBL_304352 (CHEMBL839781)
EC50
1906±n/a nM
Citation
 Chauvignac, C; Miller, CN; Srivastava, SK; Lewis, JW; Husbands, SM; Traynor, JR Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective kappa-opioid receptor antagonist. J Med Chem 48:1676-9 (2005) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50475335
Synonyms:
CHEMBL2113078
Type:
Small organic molecule
Emp. Form.:
C47H49N3O6
Mol. Mass.:
751.9085
SMILES:
[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c4C[C@@]5(O)[C@@]6([H])Cc7ccc(O)c8O[C@@]([H])(c4n(Cc4ccccc4)c21)[C@]5(CCN6CC1CC1)c78)ccc3O |TLB:51:50:23:55.28.27,THB:10:9:17:4.5.6|
Structure:
Search PDB for entries with ligand similarity: