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Target
Carbonic anhydrase 2
Ligand
BDBM50080728
Substrate
n/a
Meas. Tech.
ChEMBL_344235 (CHEMBL870709)
Ki
0.111±n/a nM
Citation
 Agrawal, VK; Singh, J; Khadikar, PV; Supuran, CT QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach. Bioorg Med Chem Lett 16:2044-51 (2006) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50080728
Synonyms:
3-{[(4-aminophenyl)sulfonyl]amino}benzenesulfonamide | 4-amino-N-(3-sulfamoylphenyl)benzenesulfonamide | 4-amino-bis-benzenesulfonamide | CHEMBL14182
Type:
Small organic molecule
Emp. Form.:
C12H13N3O4S2
Mol. Mass.:
327.379
SMILES:
Nc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)S(N)(=O)=O
Structure:
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