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Target
Reverse transcriptase protein
Ligand
BDBM50476909
Substrate
n/a
Meas. Tech.
ChEMBL_447798 (CHEMBL896807)
IC50
150±n/a nM
Citation
 Gagnon, A; Amad, MH; Bonneau, PR; Coulombe, R; DeRoy, PL; Doyon, L; Duan, J; Garneau, M; Guse, I; Jakalian, A; Jolicoeur, E; Landry, S; Malenfant, E; Simoneau, B; Yoakim, C Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases. Bioorg Med Chem Lett 17:4437-41 (2007) [PubMed]  Article 
Target
Name:
Reverse transcriptase protein
Synonyms:
Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A)
Type:
Protein
Mol. Mass.:
30203.56
Organism:
Human immunodeficiency virus 1
Description:
Q9WJQ2
Residue:
259
Sequence:
PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWTVQPIVLPEKDSWTVNDIQK
  
Inhibitor
Name:
BDBM50476909
Synonyms:
CHEMBL232378
Type:
Small organic molecule
Emp. Form.:
C22H23Cl2N5O3S
Mol. Mass.:
508.421
SMILES:
CC(C)(C)c1ccc(c(Cl)c1)-n1nnnc1SCC(=O)Nc1ccc(CCC(O)=O)cc1Cl
Structure:
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