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Target
ATP-sensitive inward rectifier potassium channel 11
Ligand
BDBM50477286
Substrate
n/a
Meas. Tech.
ChEMBL_451753 (CHEMBL901965)
EC50
646±n/a nM
Citation
 Perez-Medrano, A; Brune, ME; Buckner, SA; Coghlan, MJ; Fey, TA; Gopalakrishnan, M; Gregg, RJ; Kort, ME; Scott, VE; Sullivan, JP; Whiteaker, KL; Carroll, WA Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder. J Med Chem 50:6265-73 (2007) [PubMed]  Article 
Target
Name:
ATP-sensitive inward rectifier potassium channel 11
Synonyms:
ATP-sensitive inward rectifier potassium channel 11 | IKATP | Inward rectifier K(+) channel Kir6.2 | KCJ11_HUMAN | KCNJ11 | Potassium channel, inwardly rectifying subfamily J member 11 | Potassium channel, inwardly rectifying, subfamily J, member 11 | Sulfonylurea receptor 1, Kir6.2 | Sulfonylurea receptor 2, Kir6.2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43549.41
Organism:
Homo sapiens (Human)
Description:
Potassium channel (ATP modulatory) 0 0::Q14654
Residue:
390
Sequence:
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
  
Inhibitor
Name:
BDBM50477286
Synonyms:
CHEMBL393831
Type:
Small organic molecule
Emp. Form.:
C17H14BrCl3N6O
Mol. Mass.:
504.596
SMILES:
CC(Cl)(Cl)C(N\C(Nc1cncc(Br)c1)=N\C#N)NC(=O)c1ccc(Cl)cc1
Structure:
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