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Target
Beta-1 adrenergic receptor
Ligand
BDBM50477624
Substrate
n/a
Meas. Tech.
ChEMBL_456465 (CHEMBL887286)
EC50
25±n/a nM
Citation
 Shearer, BG; Chao, EY; Uehling, DE; Deaton, DN; Cowan, C; Sherman, BW; Milliken, T; Faison, W; Brown, K; Adkison, KK; Lee, F Synthesis and evaluation of potent and selective beta3 adrenergic receptor agonists containing heterobiaryl carboxylic acids. Bioorg Med Chem Lett 17:4670-7 (2007) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50477624
Synonyms:
CHEMBL247519
Type:
Small organic molecule
Emp. Form.:
C21H22ClN3O4
Mol. Mass.:
415.87
SMILES:
C[C@H](CNc1ccc(cc1)-c1ocnc1C(O)=O)NC[C@H](O)c1cccc(Cl)c1
Structure:
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