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Target
CAAX prenyl protease 2
Ligand
BDBM50480672
Substrate
n/a
Meas. Tech.
ChEMBL_579183 (CHEMBL1055573)
IC50
73500±n/a nM
Citation
 Williams, DE; Hollander, I; Feldberg, L; Frommer, E; Mallon, R; Tahir, A; van Soest, R; Andersen, RJ Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens. J Nat Prod 72:1106-9 (2009) [PubMed]  Article 
Target
Name:
CAAX prenyl protease 2
Synonyms:
CAAX prenyl protease 2 | FACE-2 | FACE2 | FACE2_HUMAN | Farnesylated proteins-converting enzyme 2 | Prenyl protein specific protease | Prenyl protein-specific endoprotease 2 | RCE1 | RCE1 homolog | RCE1A | RCE1B | hRCE1
Type:
PROTEIN
Mol. Mass.:
35839.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_194935
Residue:
329
Sequence:
MAALGGDGLRLLSVSRPERPPESAALGGLGPGLCCWVSVFSCLSLACSYVGSLYVWKSELPRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLADGLKVVLAPRSWARCLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCMGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGNIFLSAAFQFSYTAVFGAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAALEHPQRRPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCVLLERAGDSEAPLCS
  
Inhibitor
Name:
BDBM50480672
Synonyms:
CHEMBL561185
Type:
Small organic molecule
Emp. Form.:
C32H52O5
Mol. Mass.:
516.7523
SMILES:
[H][C@@]12CC[C@]3(C)[C@]([H])(C[C@H](OC(=O)CC(O)C(C)C)[C@]4(C)C=C([C@H](O)C[C@@]34[H])C(C)=O)[C@@]1(C)CCC[C@]2(C)CC |r,c:21|
Structure:
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