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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50481239
Substrate
n/a
Meas. Tech.
ChEMBL_604715 (CHEMBL1070535)
IC50
11100±n/a nM
Citation
 Cheng, K; Zheng, QZ; Qian, Y; Shi, L; Zhao, J; Zhu, HL Synthesis, antibacterial activities and molecular docking studies of peptide and Schiff bases as targeted antibiotics. Bioorg Med Chem 17:7861-71 (2009) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50481239
Synonyms:
CHEMBL596422
Type:
Small organic molecule
Emp. Form.:
C18H18I2N2O3
Mol. Mass.:
564.1561
SMILES:
Oc1ccccc1C(=O)NCCCC\N=C\c1cc(I)cc(I)c1O
Structure:
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