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Target
Reverse transcriptase
Ligand
BDBM50481841
Substrate
n/a
Meas. Tech.
ChEMBL_619113 (CHEMBL1102820)
IC50
19±n/a nM
Citation
 Su, DS; Lim, JJ; Tinney, E; Wan, BL; Young, MB; Anderson, KD; Rudd, D; Munshi, V; Bahnck, C; Felock, PJ; Lu, M; Lai, MT; Touch, S; Moyer, G; Distefano, DJ; Flynn, JA; Liang, Y; Sanchez, R; Prasad, S; Yan, Y; Perlow-Poehnelt, R; Torrent, M; Miller, M; Vacca, JP; Williams, TM; Anthony, NJ Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants. Bioorg Med Chem Lett 19:5119-23 (2009) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50481841
Synonyms:
CHEMBL1078056
Type:
Small organic molecule
Emp. Form.:
C18H16Cl3N3O5S
Mol. Mass.:
492.761
SMILES:
NS(=O)(=O)c1ccc(NC(=O)COC(=O)N2CCCc3cc(Cl)cc(Cl)c23)c(Cl)c1
Structure:
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