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Target
Reverse transcriptase
Ligand
BDBM50482131
Substrate
n/a
Meas. Tech.
ChEMBL_632040 (CHEMBL1110082)
IC50
13950±n/a nM
Citation
 Qin, H; Liu, C; Guo, Y; Wang, R; Zhang, J; Ma, L; Zhang, Z; Wang, X; Cui, Y; Liu, J Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorg Med Chem 18:3231-7 (2010) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50482131
Synonyms:
CHEMBL1097294
Type:
Small organic molecule
Emp. Form.:
C19H17BrN2OS
Mol. Mass.:
401.32
SMILES:
Brc1c(Cc2ccccc2)nc(SCCc2ccccc2)[nH]c1=O
Structure:
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