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Target
Beta-lactamase
Ligand
BDBM50021954
Substrate
n/a
Meas. Tech.
ChEMBL_645699 (CHEMBL1217813)
IC50
3000±n/a nM
Citation
 Poirel, L; Docquier, JD; De Luca, F; Verlinde, A; Ide, L; Rossolini, GM; Nordmann, P BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. Antimicrob Agents Chemother 54:533-5 (2010) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
3.5.2.6 | Beta-lactamase
Type:
PROTEIN
Mol. Mass.:
30982.09
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_117206
Residue:
283
Sequence:
MKLLLYPLLLFLVIPAFAQADFEHAISDLEAHNQAKIGVALVSENGNLIQGYRANERFAMCSTFKLPLAALVLSRIDAGEENPERKLHYDSAFLEEYAPAAKRYVATGYMTVTEAIQSALQLSDNAAANLLLKEVGGPPLLTKYFRSLGDKVSRFDRIEPTLNTNTPGDERDTTTPMSMAQTVSKLIFGDTLTYKSKGQLRRLLIGNQTGDKTIRAGLPDSWVTGDKTGSCANGGRNDVAFFITTAGKKYVLSVYTNAPELQGEERALLIASVAKLARQYVVH
  
Inhibitor
Name:
BDBM50021954
Synonyms:
(2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | (S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam) | CHEMBL403 | CP-45,899 | SULBACTAM | UNASYN | US20230322715, Compound ALK-09 | US9120808, Sulbactam sodium salt
Type:
Small organic molecule
Emp. Form.:
C8H11NO5S
Mol. Mass.:
233.242
SMILES:
CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O |r|
Structure:
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