Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50028628
Substrate
n/a
Meas. Tech.
ChEBML_142786
Ki
1679000±n/a nM
Citation
 Rafferty, MF; Wilson, DS; Monn, JA; Krass, P; Borchardt, RT; Grunewald, GL Importance of the aromatic ring in adrenergic amines. 7. Comparison of the stereoselectivity of norepinephrine N-methyltransferase for aromatic vs. nonaromatic substrates and inhibitors. J Med Chem 25:1198-204 (1983) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50028628
Synonyms:
(1R)-1-phenylethanamine | (R)-alpha-methylbenzenemethanamine | (alphaR)-alpha-methylbenzenemethanamine | CHEMBL19969 | D-alpha-methylbenzylamine
Type:
Small organic molecule
Emp. Form.:
C8H11N
Mol. Mass.:
121.1796
SMILES:
C[C@@H](N)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: