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Target
Penicillin-binding protein 2B
Ligand
BDBM50378857
Substrate
n/a
Meas. Tech.
ChEMBL_726002 (CHEMBL1678598)
IC50
3180±n/a nM
Citation
 Davies, TA; He, W; Bush, K; Flamm, RK Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. Antimicrob Agents Chemother 54:4510-2 (2010) [PubMed]  Article 
Target
Name:
Penicillin-binding protein 2B
Synonyms:
PBP2_STRPN | Penicillin-binding protein 2B | pbp2b | pbp2b | penA
Type:
PROTEIN
Mol. Mass.:
73859.38
Organism:
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Description:
ChEMBL_103544
Residue:
680
Sequence:
MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYYLADPEIYKKIVEALPSEKRLDSDGNRLSESELYNNAVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQSIVFQGSAPINSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRSTFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYHPMN
  
Inhibitor
Name:
BDBM50378857
Synonyms:
CEFTOBIPROLE | Zeftera | Zevtera
Type:
Small organic molecule
Emp. Form.:
C20H22N8O6S2
Mol. Mass.:
534.569
SMILES:
Nc1nc(ns1)C(N=O)C(=O)N[C@H]1[C@H]2SCC(C=C3CCN([C@@H]4CCNC4)C3=O)=C(N2C1=O)C(O)=O |r,w:17.17,c:31|
Structure:
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