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Target
Presenilin-1
Ligand
BDBM50484105
Substrate
n/a
Meas. Tech.
ChEMBL_762755 (CHEMBL1816006)
IC50
24000±n/a nM
Citation
 Zall, A; Kieser, D; Höttecke, N; Naumann, EC; Thomaszewski, B; Schneider, K; Steinbacher, DT; Schubenel, R; Masur, S; Baumann, K; Schmidt, B NSAID-derived ?-secretase modulation requires an acidic moiety on the carbazole scaffold. Bioorg Med Chem 19:4903-9 (2011) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50484105
Synonyms:
CHEMBL1812408
Type:
Small organic molecule
Emp. Form.:
C39H40N2O5
Mol. Mass.:
616.7453
SMILES:
CCCCCCCCn1c2ccccc2c2ccc(OC3=C(O)C(Cc4ccc5OCOc5c4)N(Cc4ccccc4)C3=O)cc12 |c:21|
Structure:
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