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Target
Transcription factor 7-like 2
Ligand
BDBM50484950
Substrate
n/a
Meas. Tech.
ChEMBL_813063 (CHEMBL2020637)
IC50
3500±n/a nM
Citation
 Mao, Y; Lin, N; Tian, W; Han, X; Han, X; Huang, Z; An, J Design, synthesis, and biological evaluation of new diaminoquinazolines as ?-catenin/Tcf4 pathway inhibitors. J Med Chem 55:1346-59 (2012) [PubMed]  Article 
Target
Name:
Transcription factor 7-like 2
Synonyms:
HMG box transcription factor 4 | T-cell factor 4 | T-cell-specific transcription factor 4 | TCF-4 | TCF4 | TCF7L2 | TF7L2_HUMAN | hTCF-4
Type:
PROTEIN
Mol. Mass.:
67939.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107937
Residue:
619
Sequence:
MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGSLSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQPQPLSLVTKSLE
  
Inhibitor
Name:
BDBM50484950
Synonyms:
CHEMBL569102
Type:
Small organic molecule
Emp. Form.:
C23H20FN5O
Mol. Mass.:
401.4362
SMILES:
CNc1nc(NCc2ccc(NC(=O)c3ccc(F)cc3)cc2)c2ccccc2n1
Structure:
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