Reaction Details Report a problem with these data
Target
Transcription factor 7-like 2
Ligand
BDBM50484964
Substrate
n/a
Meas. Tech.
ChEMBL_813063 (CHEMBL2020637)
IC50
>5000±n/a nM
Citation
 Mao, Y; Lin, N; Tian, W; Han, X; Han, X; Huang, Z; An, J Design, synthesis, and biological evaluation of new diaminoquinazolines as ?-catenin/Tcf4 pathway inhibitors. J Med Chem 55:1346-59 (2012) [PubMed]  Article 
Target
Name:
Transcription factor 7-like 2
Synonyms:
HMG box transcription factor 4 | T-cell factor 4 | T-cell-specific transcription factor 4 | TCF-4 | TCF4 | TCF7L2 | TF7L2_HUMAN | hTCF-4
Type:
PROTEIN
Mol. Mass.:
67939.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107937
Residue:
619
Sequence:
MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGSLSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQPQPLSLVTKSLE
  
Inhibitor
Name:
BDBM50484964
Synonyms:
CHEMBL2018735
Type:
Small organic molecule
Emp. Form.:
C34H40FN7O
Mol. Mass.:
581.7261
SMILES:
CC1CN(CCN1)c1nc(NCc2ccc(cc2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)c2cc(C)ccc2n1
Structure:
Search PDB for entries with ligand similarity: