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Target
Reverse transcriptase
Ligand
BDBM50478026
Substrate
n/a
Meas. Tech.
ChEMBL_854340 (CHEMBL2154560)
IC50
2.7±n/a nM
Citation
 Ma, XD; He, QQ; Zhang, X; Yang, SQ; Yang, LM; Gu, SX; Zheng, YT; Chen, FE; Dai, HF Synthesis, structure-activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors. Eur J Med Chem 58:504-12 (2012) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50478026
Synonyms:
CHEMBL203420 | GW678248 | GW8248
Type:
Small organic molecule
Emp. Form.:
C23H17Cl2N3O5S
Mol. Mass.:
518.369
SMILES:
Cc1cc(ccc1NC(=O)COc1ccc(Cl)cc1C(=O)c1cc(Cl)cc(c1)C#N)S(N)(=O)=O
Structure:
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