Reaction Details Report a problem with these data
Target
Substance-P receptor
Ligand
BDBM50030140
Substrate
n/a
Meas. Tech.
ChEMBL_143027 (CHEMBL880850)
IC50
125±n/a nM
Citation
 MacLeod, AM; Merchant, KJ; Brookfield, F; Kelleher, F; Stevenson, G; Owens, AP; Swain, CJ; Casiceri, MA; Sadowski, S; Ber, E Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor. J Med Chem 37:1269-74 (1994) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50030140
Synonyms:
CHEMBL281804 | [(S)-1-(3,5-Dimethyl-benzyloxycarbonyl)-2-(1H-indol-3-yl)-ethyl]-trimethyl-ammonium | [1-(3,5-Dimethyl-benzyloxycarbonyl)-2-(1H-indol-3-yl)-ethyl]-trimethyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C23H29N2O2
Mol. Mass.:
365.488
SMILES:
Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1
Structure:
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