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Target
Substance-K receptor
Ligand
BDBM50030140
Substrate
n/a
Meas. Tech.
ChEMBL_143058 (CHEMBL750305)
IC50
>5000±n/a nM
Citation
 MacLeod, AM; Merchant, KJ; Brookfield, F; Kelleher, F; Stevenson, G; Owens, AP; Swain, CJ; Casiceri, MA; Sadowski, S; Ber, E Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor. J Med Chem 37:1269-74 (1994) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50030140
Synonyms:
CHEMBL281804 | [(S)-1-(3,5-Dimethyl-benzyloxycarbonyl)-2-(1H-indol-3-yl)-ethyl]-trimethyl-ammonium | [1-(3,5-Dimethyl-benzyloxycarbonyl)-2-(1H-indol-3-yl)-ethyl]-trimethyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C23H29N2O2
Mol. Mass.:
365.488
SMILES:
Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1
Structure:
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